The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: II. Comparison Between Glucagon- and Fluoride-Stimulated Activities
- Title:
- The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: II. Comparison Between Glucagon- and Fluoride-Stimulated Activities
- Creator:
-
Pohl, Stephen L.
Birnbaumer, Lutz
Rodbell, Martin, 1925-1998 - Date:
- 25 March 1971
- Description:
- The second in a now-classic series of five articles in which Rodbell concluded that GTP was likely the active biological factor in separating glucagon from the cell's receptor, which had important implications for the treatment of various disorders and diseases. In this article, he suggested that glucagon and inorganic fluoride activate the enzyme adenyl cyclase, an important component of some intracellular signaling pathways, by different mechanisms and possibly through different molecular entities, which indicated more than one mode of signal transduction.
- Periodical:
- Journal of Biological Chemistry
- Publisher:
- American Society for Biochemistry and Molecular Biology
- Location:
- Box: 19. Folder: 10
- Rights:
- Reproduced with permission of the American Society for Biochemistry and Molecular Biology.
- Genre:
- Articles
- Subject:
- Adenylyl Cyclases, Cell Membrane, Enzymes, Fluorides, Glucagon, and Pharmacology
- Format:
- Text
- Extent:
- 4 pages
- Relation:
- The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: I. Properties, 1971 The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: III. Binding of Glucagon: Method of Assay and Specificity, 1971 The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: IV. Effects of Guanyl Nucleotides on Binding of 125 I-Glucagon, 1971 The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: V. An Obligatory Role of Guanyl Nucleotides in Glucagon Action, 1971
- Language:
- English
- Legacy Source Citation:
- Periodical. Birnbaumer, Lutz, Stephen L. Pohl, and Martin Rodbell. "The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: II. Comparison Between Glucagon- and Fluoride-Stimulated Activities." Journal of Biological Chemistry 246, 6 (25 March 1971): 1857-1860. Article. 4 Images.. Journal of Biological Chemistry
- Legacy ID:
- GGAAAX
- NLM ID:
- 101584917X24
- Profiles Collection:
- The Martin Rodbell Papers
- Shareable Link:
- https://profiles.nlm.nih.gov/101584917X24
- Story Section:
- Signal Transduction and the Discovery of G-Proteins, 1969-1980