The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: III. Binding of Glucagon: Method of Assay and Specificity
- Title:
- The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: III. Binding of Glucagon: Method of Assay and Specificity
- Creator:
-
Krans, Hendrik Michiel Jan
Pohl, Stephen L.
Birnbaumer, Lutz
Rodbell, Martin, 1925-1998 - Date:
- 25 March 1971
- Description:
- The third in a now-classic series of five articles in which Rodbell concluded that GTP was likely the active biological factor in separating glucagon from the cell's receptor, which had important implications for the treatment of various disorders and diseases. In this article, Rodbell established that the glucagon receptor is involved in the activation of the enzyme adenyl cyclase and that intracellular signaling is achieved through specific GTP-binding heterotrimeric G-proteins.
- Periodical:
- Journal of Biological Chemistry
- Publisher:
- American Society for Biochemistry and Molecular Biology
- Location:
- Box: 19. Folder: 10
- Rights:
- Reproduced with permission of the American Society for Biochemistry and Molecular Biology.
- Genre:
- Articles
- Subject:
- Adenylyl Cyclases, Binding Sites, Cell Membrane, Enzymes, Glucagon, and Pharmacology
- Format:
- Text
- Extent:
- 11 pages
- Relation:
- The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: I. Properties, 1971 The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: II. Comparison Between Glucagon- and Fluoride-Stimulated Activities, 1971 The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: IV. Effects of Guanyl Nucleotides on Binding of 125 I-Glucagon, 1971 The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: V. An Obligatory Role of Guanyl Nucleotides in Glucagon Action, 1971
- Language:
- English
- Legacy Source Citation:
- Periodical. Rodbell, Martin, Hendrik Michiel Jan Krans, Stephen L. Pohl, and Lutz Birnbaumer. "The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: III. Binding of Glucagon: Method of Assay and Specificity." Journal of Biological Chemistry 246, 6 (25 March 1971): 1861-1871. Article. 11 Images.. Journal of Biological Chemistry
- Legacy ID:
- GGAAAY
- NLM ID:
- 101584917X25
- Profiles Collection:
- The Martin Rodbell Papers
- Shareable Link:
- https://profiles.nlm.nih.gov/101584917X25
- Story Section:
- Signal Transduction and the Discovery of G-Proteins, 1969-1980