GTP Stimulates and Inhibits Adenylate Cyclase in Fat Cell Membranes through Distinct Regulatory Processes
- Title:
- GTP Stimulates and Inhibits Adenylate Cyclase in Fat Cell Membranes through Distinct Regulatory Processes
- Creator:
-
Yamamura, Hiromi, 1961-
Lad, Pramod M.
Rodbell, Martin, 1925-1998 - Date:
- 25 November 1977
- Description:
- The first of two articles in which Rodbell indicated that in addition to transducing hormone signals across the membrane, the G-protein could also inhibit signaling at the discriminator point. He provided evidence that G-proteins at the cellular receptors were sophisticated enough to both inhibit and activate signal transduction.
- Periodical:
- Journal of Biological Chemistry
- Publisher:
- American Society for Biochemistry and Molecular Biology
- Location:
- Box: 19. Folder: 12
- Rights:
- Reproduced with permission of the American Society for Biochemistry and Molecular Biology.
- Genre:
- Articles
- Subject:
- Adenylyl Cyclases, Guanosine Triphosphate, Hormones, and Metabolism
- Format:
- Text
- Extent:
- 3 pages
- Relation:
- Letter from Joshua Lederberg to Michael Doudoroff, 1948
- Language:
- English
- Legacy Source Citation:
- Periodical. Yamamura, Hirohei, Pramod M. Lad, and Martin Rodbell. "GTP Stimulates and Inhibits Adenylate Cyclase in Fat Cell Membranes through Distinct Regulatory Processes." Journal of Biological Chemistry 252, 22 (25 November 1977): 7964-7966. Article. 3 Images.. Journal of Biological Chemistry
- Legacy ID:
- GGAABB
- NLM ID:
- 101584917X28
- Profiles Collection:
- The Martin Rodbell Papers
- Shareable Link:
- https://profiles.nlm.nih.gov/101584917X28
- Story Section:
- Signal Transduction and the Discovery of G-Proteins, 1969-1980