The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: IV. Effects of Guanyl Nucleotides on Binding of 125 I-Glucagon
- Title:
- The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: IV. Effects of Guanyl Nucleotides on Binding of 125 I-Glucagon
- Creator:
-
Krans, Hendrik Michiel Jan
Pohl, Stephen L.
Birnbaumer, Lutz
Rodbell, Martin, 1925-1998 - Date:
- 25 March 1971
- Description:
- The fourth in a now-classic series of five articles in which Rodbell concluded that GTP was likely the active biological factor in separating glucagon from the cell's receptor, which had important implications for the treatment of various disorders and diseases. In the last two articles of this series, Rodbell demonstrated that GTP affected the binding of glucagon to its receptors and was necessary for glucagon to activate adenyl cyclase, an important component of some intracellular signaling pathways.
- Periodical:
- Journal of Biological Chemistry
- Publisher:
- American Society for Biochemistry and Molecular Biology
- Location:
- Box: 19. Folder: 10
- Rights:
- Reproduced with permission of the American Society for Biochemistry and Molecular Biology.
- Genre:
- Articles
- Subject:
- Adenylyl Cyclases, Binding Sites, Iodine Isotopes, Glucagon, Guanine Nucleotides, and Pharmacology
- Format:
- Text
- Extent:
- 5 pages
- Relation:
- The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: I. Properties, 1971 The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: II. Comparison Between Glucagon- and Fluoride-Stimulated Activities, 1971 The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: III. Binding of Glucagon: Method of Assay and Specificity, 1971 The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: V. An Obligatory Role of Guanyl Nucleotides in Glucagon Action, 1971
- Language:
- English
- Legacy Source Citation:
- Periodical. Rodbell, Martin, Hendrik Michiel Jan Krans, Stephen L. Pohl, and Lutz Birnbaumer. "The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: IV. Effects of Guanyl Nucleotides on Binding of 125 I-Glucagon." Journal of Biological Chemistry 246, 6 (25 March 1971): 1872-1876. Article. 5 Images.. Journal of Biological Chemistry
- Legacy ID:
- GGAAAZ
- NLM ID:
- 101584917X26
- Profiles Collection:
- The Martin Rodbell Papers
- Shareable Link:
- https://profiles.nlm.nih.gov/101584917X26
- Story Section:
- Signal Transduction and the Discovery of G-Proteins, 1969-1980